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ELF5: A Molecular Clock for Breast Aging and Cancer Susceptibility

19 Jan 2024

Abstract excerpt

Breast cancer is predominantly an age-related disease, with aging serving as the most significant risk factor, compounded by germline mutations in high-risk genes like BRCA1/2. Aging induces architectural changes in breast tissue, particularly affecting luminal epithelial cells by diminishing lineage-specific molecular profiles and adopting myoepithelial-like characteristics. ELF5 is an important transcription...

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PMID: 38275872
DOI: 10.3390/cancers16020431

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