Article
Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers.
Nature communications - 7 Aug 2014
Veeraraghavan Jamunarani, Tan Ying, Cao Xi-Xi, Kim Jin Ah, Wang Xian, Chamness Gary C, Maiti Sourindra N, Cooper Laurence J N, Edwards Dean P, Contreras Alejandro, Hilsenbeck Susan G, Chang Eric C, Schiff Rachel, Wang Xiao-Song
Abstract excerpt
Characterizing the genetic alterations leading to the more aggressive forms of oestrogen receptor-positive (ER+) breast cancers is of critical significance in breast cancer management. Here we identify recurrent rearrangements between the oestrogen receptor gene ESR1 and its neighbour CCDC170, which are enriched in the more aggressive and endocrine-resistant luminal B tumours, through large-scale analyses of...
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