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Article

Landscape analysis of adjacent gene rearrangements reveals BCL2L14-ETV6 gene fusions in more aggressive triple-negative breast cancer.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2020

Lee Sanghoon, Hu Yiheng, Loo Suet Kee, Tan Ying, Bhargava Rohit, Lewis Michael T, Wang Xiao-Song

Abstract excerpt

Triple-negative breast cancer (TNBC) accounts for 10 to 20% of breast cancer, with chemotherapy as its mainstay of treatment due to lack of well-defined targets, and recent genomic sequencing studies have revealed a paucity of TNBC-specific mutations. Recurrent gene fusions comprise a class of viable genetic targets in solid tumors; however, their role in breast cancer remains underappreciated due to the...

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Share to ETS Translocation Variant 6 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32321829
DOI: 10.1073/pnas.1921333117
PMCID: PMC7211963

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