Article
An integrative analysis of the age-associated multi-omic landscape across cancers.
Nature communications - 20 Apr 2021
Chatsirisupachai Kasit, Lesluyes Tom, Paraoan Luminita, Van Loo Peter, de Magalhães João Pedro
Abstract excerpt
Age is the most important risk factor for cancer, as cancer incidence and mortality increase with age. However, how molecular alterations in tumours differ among patients of different age remains largely unexplored. Here, using data from The Cancer Genome Atlas, we comprehensively characterise genomic, transcriptomic and epigenetic alterations in relation to patients' age across cancer types. We show that tumours...
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