Article
SMC6 is an essential gene in mice, but a hypomorphic mutant in the ATPase domain has a mild phenotype with a range of subtle abnormalities.
DNA repair - 1 May 2013
Ju Limei, Wing Jonathan, Taylor Elaine, Brandt Renata, Slijepcevic Predrag, Horsch Marion, Rathkolb Birgit, Rácz Ildikó, Becker Lore, Hans Wolfgang, Adler Thure, Beckers Johannes, Rozman Jan, Klingenspor Martin, Wolf Eckhard, Zimmer Andreas, Klopstock Thomas, Busch Dirk H, Gailus-Durner Valérie, Fuchs Helmut, de Angelis Martin Hrabě, van der Horst Gilbertus, Lehmann Alan R
Abstract excerpt
Smc5-6 is a highly conserved protein complex related to cohesin and condensin involved in the structural maintenance of chromosomes. In yeasts the Smc5-6 complex is essential for proliferation and is involved in DNA repair and homologous recombination. siRNA depletion of genes involved in the Smc5-6 complex in cultured mammalian cells results in sensitivity to some DNA damaging agents. In order to gain further...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.