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Article

ALKBH5 as a therapeutic target for hypertension: Inhibiting vascular smooth muscle cell phenotypic switch via the TEAD3/PDZK1 axis.

Translational research : the journal of laboratory and clinical medicine - 1 Aug 2026

Luo Liying, Wang Lei, Ma Dan, Liu Wenxiu, Shi Zhiyu, Liu Chunnan, Zhao Meng, Bai Yufeng, Lu Jiukun, Chi Jinyu

Abstract excerpt

Hypertension is a chronic disease accompanied by vascular remodeling. As an m6A demethylase, ALKBH5 is implicated in cardiovascular diseases. Herein, we demonstrated that ALKBH5 expression was upregulated in the aortic tissues of spontaneously hypertensive rats (SHR), with predominant localization in vascular smooth muscle cells (VSMCs). To define ALKBH5 function, we generated an SM22α-driven, VSMC-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Rats, Inbred SHR

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Source

Identifiers

PMID: 42269764
DOI: 10.1016/j.trsl.2026.06.004

Genes

ALKBH5
PDZK1
TEAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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