Article
Inducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection.
Experimental & molecular medicine - 1 Oct 2021
Pyun Jung-Hoon, Ahn Byeong-Yun, Vuong Tuan Anh, Kim Su Woo, Jo Yunju, Jeon Jaehyung, Baek Seung Ho, Kim Jaewon, Park Sungsu, Bae Gyu-Un, Choi Jun-Hyuk, Kim Jae-Ryong, Ryu Dongryeol, Lee Sang-Jin, Kang Jong-Sun
Abstract excerpt
Vascular smooth muscle cells (VSMCs) have remarkable plasticity in response to diverse environmental cues. Although these cells are versatile, chronic stress can trigger VSMC dysfunction, which ultimately leads to vascular diseases such as aortic aneurysm and atherosclerosis. Protein arginine methyltransferase 1 (Prmt1) is a major enzyme catalyzing asymmetric arginine dimethylation of proteins that are sources of...
Topics
- Aged
- Aortic Dissection
- Animals
- Aortic Aneurysm
- Cells, Cultured
- Humans
- Mice
- Muscle Contraction
- Muscle, Smooth, Vascular
- Myocytes, Smooth Muscle