Article
N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells.
Cellular and molecular life sciences : CMLS - 12 Jun 2024
Kang Kang, Sun Chuannan, Li Hui, Liu Xiaojia, Deng Jingyuan, Chen Silei, Zeng Le, Chen Jiahao, Liu Xinyi, Kuang Jiahao, Xiang Jingjing, Cheng Jingqian, Liao Xiaoyun, Lin Mujin, Zhang Xingshi, Zhan Chuzhi, Liu Sisi, Wang Jun, Niu Yanqin, Liu Cuilian, Liang Cai, Zhu Jinsheng, Liang Shuxin, Tang Haiyang, Gou Deming
Abstract excerpt
Pulmonary hypertension (PH) is characterized by vascular remodeling predominantly driven by a phenotypic switching in pulmonary artery smooth muscle cells (PASMCs). However, the underlying mechanisms for this phenotypic alteration remain incompletely understood. Here, we identified that RNA methyltransferase METTL3 is significantly elevated in the lungs of hypoxic PH (HPH) mice and rats, as well as in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.