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Article

SAMD4A inhibits abdominal aortic aneurysm development and VSMC phenotypic transformation through targeting KDM2B.

Journal of advanced research - 1 Jan 2026

Chen Qing, Liu Shenrong, Zhou Haobin, Wang Junfen, Xiao Xiaoyong, Chen Guojun, Du Juan, Zhong Lintao, Song Haoyu, Huang Xianying

Abstract excerpt

INTRODUCTION: Abdominal aortic aneurysm (AAA) is a fatal vascular disease without effective drug treatments. Pathological vascular smooth muscle cell (VSMC) phenotypic transformation is the underlying cause of AAA. However, the underlying mechanism has not been fully elucidated. OBJECTIVE: We aimed to determine whether the RNA binding protein SAMD4A suppresses VSMC phenotype transformation and inhibits AAA...

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Source

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Identifiers

PMID: 40081568
DOI: 10.1016/j.jare.2025.03.018
PMCID: PMC12766201

Genes

SAMD4A
KDM2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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