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Article

DTX1 Regulates Aortic Dissection Progression by Modulating Vascular Smooth Muscle Cell Phenotypic Switching via Ubiquitination of ITGA5.

Cardiovascular drugs and therapy - 1 Oct 2026

Wang Dong, Yang Lingbo, Zong Junqing

Abstract excerpt

BACKGROUND: Aortic dissection (AD) is a life-threatening vascular disorder characterized by medial degeneration and phenotypic switching of vascular smooth muscle cells (VSMCs). While integrin subunit alpha 5 (ITGA5) has been implicated in VSMC plasticity, the upstream molecular mechanisms governing its regulation remain poorly defined. METHODS: Publicly available transcriptomic datasets were analyzed using...

Read the complete abstract on PubMed

Topics

Animals
Humans
Muscle, Smooth, Vascular
Ubiquitination
Myocytes, Smooth Muscle
Phenotype
Integrin alpha5

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Disease Progression

HEK293 Cells

Aortic Dissection

Disease Models, Animal

Male

Mice, Inbred C57BL

Ubiquitin-Protein Ligases

Mice

Cells, Cultured

Vascular Remodeling

Integrins

Source

Identifiers

PMID: 42090073
DOI: 10.1007/s10557-026-07877-4

Genes

ITGA5
DTX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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