Article
SOX6 enhances vascular smooth muscle cell phenotypic switching and elevates blood pressure by activating autophagy.
Animal models and experimental medicine - 1 Aug 2025
Ling Qianhui, Dong Xilan, Mao Liyan, Huang Chengjun, Cong Linjing, Zhang Haizeng, Cai Jun, Chen Zhenzhen
Abstract excerpt
BACKGROUND: SOX6 has been shown to play a crucial role in the development of the cardiovascular system. However, its potential role in hypertension and vascular function remains unclear. METHODS: In vascular smooth muscle cells (VSMCs), we employed gain- and loss-of-function approaches combined with RNA sequencing, autophagy flux assessment, and phenotype characterization. Additionally, we established a mouse...
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