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Development of a User-Friendly Pipeline for Mutational Analyses of HIV Using Ultra-Accurate Maximum-Depth Sequencing.

Viruses - 11 Jul 2021

Meissner Morgan E, Julik Emily J, Badalamenti Jonathan P, Arndt William G, Mills Lauren J, Mansky Louis M

Abstract excerpt

Human immunodeficiency virus type 2 (HIV-2) accumulates fewer mutations during replication than HIV type 1 (HIV-1). Advanced studies of HIV-2 mutagenesis, however, have historically been confounded by high background error rates in traditional next-generation sequencing techniques. In this study, we describe the adaptation of the previously described maximum-depth sequencing (MDS) technique to studies of both...

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Identifiers

PMID: 34372543
DOI: 10.3390/v13071338
PMCID: PMC8310143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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