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Article

Optimization of a deep mutational scanning workflow to improve quantification of mutation effects on protein-protein interactions.

BMC genomics - 24 Jun 2024

Bendel Alexandra M, Skendo Kristjana, Klein Dominique, Shimada Kenji, Kauneckaite-Griguole Kotryna, Diss Guillaume

Abstract excerpt

Deep Mutational Scanning (DMS) assays are powerful tools to study sequence-function relationships by measuring the effects of thousands of sequence variants on protein function. During a DMS experiment, several technical artefacts might distort non-linearly the functional score obtained, potentially biasing the interpretation of the results. We therefore tested several technical parameters in the deepPCA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38914936
DOI: 10.1186/s12864-024-10524-7
PMCID: PMC11194945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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