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Article

High-throughput profiling of point mutations across the HIV-1 genome

1 Dec 2014

Abstract excerpt

BACKGROUND: The HIV-1 pandemic is not the result of a static pathogen but a large genetically diverse and dynamic viral population. The virus is characterized by a highly mutable genome rendering efforts to design a universal vaccine a significant challenge and drives the emergence of drug resistant variants upon antiviral pressure. Gaining a comprehensive understanding of the mutational tolerance of each HIV-1...

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PMID: 25522661
DOI: 10.1186/s12977-014-0124-6

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