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Article

Mouse strain differences in metabolic fluxes and function of ex vivo working hearts

1 Nov 2013

Abstract excerpt

In mice, genetic background is known to influence various parameters, including cardiac function. Its impact on cardiac energy substrate metabolism-a factor known to be closely related to function and contributes to disease development-is, however, unclear. This was examined in this study. In commonly used control mouse substrains SJL/JCrNTac, 129S6/SvEvTac, C57Bl/6J, and C57Bl/6NCrl, we assessed the functional...

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PMID: 24186097
DOI: 10.1152/ajpheart.00465.2013

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