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Article

Differences in molecular phenotype in mouse and human hypertrophic cardiomyopathy.

Scientific reports - 23 Jun 2021

Vakrou Styliani, Liu Yamin, Zhu Li, Greenland Gabriela V, Simsek Bahadir, Hebl Virginia B, Guan Yufan, Woldemichael Kirubel, Talbot Conover C, Aon Miguel A, Fukunaga Ryuya, Abraham M Roselle

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is characterized by phenotypic heterogeneity. We investigated the molecular basis of the cardiac phenotype in two mouse models at established disease stage (mouse-HCM), and human myectomy tissue (human-HCM). We analyzed the transcriptome in 2 mouse models with non-obstructive HCM (R403Q-MyHC, R92W-TnT)/littermate-control hearts at 24 weeks of age, and in myectomy tissue of...

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Identifiers

PMID: 34162896
DOI: 10.1038/s41598-021-89451-6
PMCID: PMC8222321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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