Article

Modeling Cardiomyocyte Signaling and Metabolism Predicts Genotype to Phenotype Mechanisms in Hypertrophic Cardiomyopathy

2023-09-26

Abstract excerpt

Familial hypertrophic cardiomyopathy (HCM) is a significant precursor of heart failure and sudden cardiac death, primarily caused by mutations in sarcomeric and structural proteins. Despite the extensive research on the HCM genotype, the complex, context-specific nature of many signaling and metabolic pathways linking the HCM genotype to phenotype has hindered therapeutic advancements for patients. To address thes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11adaa5b-beb3-5cee-9fd5-16298d48fc60
DOI: 10.1101/2023.09.25.559356

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modeling Cardiomyocyte Signaling and Metabolism Predicts Genotype to Phenotype Mechanisms in Hypertrophic CardiomyopathyDOI 10.1101/2023.09.25.559356Read

Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy.Semantic proximity Read

Signaling network model of cardiomyocyte morphological changes in familial cardiomyopathySemantic proximity Read

Lipid metabolism drives allele-specific early-stage hypertrophic cardiomyopathySemantic proximity Read

Genetic Mutations and Mitochondrial Redox Signaling as Modulating Factors in Hypertrophic Cardiomyopathy: A Scoping Review.Semantic proximity Read

Targeting lipid metabolism as a new therapeutic strategy for inherited cardiomyopathiesSemantic proximity Read

Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling.Semantic proximity Read

An In Silico Cardiomyocyte Reveals the Impact of Changes in CaMKII Signalling on Cardiomyocyte Contraction Kinetics in Hypertrophic Cardiomyopathy.Semantic proximity Read

Differences in molecular phenotype in mouse and human hypertrophic cardiomyopathy.Semantic proximity Read

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.Semantic proximity Read

Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopathy.Semantic proximity Read

Proteogenomics of Hypertrophic Cardiomyopathy Reveals Subtype-Specific Therapy.Semantic proximity Read

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits.Semantic proximity Read