Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion.

Trends in genetics : TIG - 1 May 2003

Ashrafian Houman, Redwood Charles, Blair Edward, Watkins Hugh

Abstract excerpt

Genetic analysis of hypertrophic cardiomyopathy (HCM), a mendelian form of cardiac hypertrophy, indicates that the primary defect is in sarcomeric function. However, the initial proposal that depressed myocardial contraction leads to a 'compensatory' hypertrophy has proven inconsistent with laboratory and clinical evidence. Drawing on observations of mutant contractile protein function, together with mouse models...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Cardiomyopathy, Hypertrophic
Share to Energy Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Markers

Share to Mutation

Share to Myocardium

Source

Identifiers

PMID: 12711218
DOI: 10.1016/S0168-9525(03)00081-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion.PMID 12711218Read ↗

Mechano-energetic uncoupling in hypertrophic cardiomyopathy: Pathophysiological mechanisms and therapeutic opportunitiesSemantic proximity Read ↗

Critical Evaluation of Current Hypotheses for the Pathogenesis of Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy.Semantic proximity Read ↗

Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits.Semantic proximity Read ↗

Mechanical and energetic consequences of HCM-causing mutations.Semantic proximity Read ↗

Heterozygous MYH7 R403Q mutation impairs left atrial mitochondrial function in a Yucatan mini-pig model of genetic nonobstructive hypertrophic cardiomyopathy.Semantic proximity Read ↗

[Cardiomyopathies due to defective energy metabolism: morphological and functional features].Semantic proximity Read ↗

Gene-specific increase in the energetic cost of contraction in hypertrophic cardiomyopathy caused by thick filament mutations.Semantic proximity Read ↗

Metabolic remodeling in hypertrophied and failing myocardium: a review.Semantic proximity Read ↗

Metabolic Alterations in Inherited CardiomyopathiesSemantic proximity Read ↗

Cardiomyopathies Due to Left Ventricular Noncompaction, Mitochondrial and Storage Diseases, and Inborn Errors of Metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.