Article
Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy.
Circulation - 23 Nov 2021
Ranjbarvaziri Sara, Kooiker Kristina B, Ellenberger Mathew, Fajardo Giovanni, Zhao Mingming, Vander Roest Alison Schroer, Woldeyes Rahel A, Koyano Tiffany T, Fong Robyn, Ma Ning, Tian Lei, Traber Gavin M, Chan Frandics, Perrino John, Reddy Sushma, Chiu Wah, Wu Joseph C, Woo Joseph Y, Ruppel Kathleen M, Spudich James A, Snyder Michael P, Contrepois Kévin, Bernstein Daniel
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the cellular level, HCM mutations most commonly enhance force production, leading to higher energy demands. Despite significant advances in elucidating sarcomeric structure-function relationships, there is still much to be learned about the...
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