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Article

Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2008

Essop M Faadiel, Camp Heidi S, Choi Cheol Soo, Sharma Saumya, Fryer Ryan M, Reinhart Glenn A, Guthrie Patrick H, Bentebibel Assia, Gu Zeiwei, Shulman Gerald I, Taegtmeyer Heinrich, Wakil Salih J, Abu-Elheiga Lutfi

Abstract excerpt

The cardiac-enriched isoform of acetyl-CoA carboxylase (ACC2) is a key regulator of mitochondrial fatty acid (FA) uptake via carnitine palmitoyltransferase 1 (CPT1). To test the hypothesis that oxidative metabolism is upregulated in hearts from animals lacking ACC2 (employing a transgenic Acc2-mutant mouse), we assessed cardiac function in vivo and determined rates of myocardial substrate oxidation ex vivo. When...

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Identifiers

PMID: 18487439
DOI: 10.1152/ajpheart.91489.2007
PMCID: PMC2494759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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