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Article

Unmasking the "targetless" illusion: branched clonal evolution of TERT and KIT in acral melanoma revealed by sequential multi-site biopsies- a case report.

Frontiers in immunology - 1 Jan 2026

Fu Yuqiao, Li Peng, Li Ke, Jiang Lei, Liang Yingzi, Shao Lipei, Zhang Ya, Ge Chunlei, Zhang Zhaoqi, Wang Ying, Li Ruilei

Abstract excerpt

Tumor clonal evolution and spatiotemporal heterogeneity are key drivers of therapeutic resistance in melanoma, often driven by selection pressures generated by systemic therapy. Genetic testing plays a key role in guiding targeted therapies, but a single biopsy may not fully reflect the mutational landscape. This paper reports a case of metastatic acral melanoma that demonstrated dynamic branching clonal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42245639
DOI: 10.3389/fimmu.2026.1810921
PMCID: PMC13230091

Genes

KIT
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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