The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas.

doi:10.1158/1078-0432.CCR-20-2984

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Article

The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2021

Makohon-Moore Alvin P, Lipson Evan J, Hooper Jody E, Zucker Amanda, Hong Jungeui, Bielski Craig M, Hayashi Akimasa, Tokheim Collin, Baez Priscilla, Kappagantula Rajya, Kohutek Zachary, Makarov Vladimir, Riaz Nadeem, Postow Michael A, Chapman Paul B, Karchin Rachel, Socci Nicholas D, Solit David B, Chan Timothy A, Taylor Barry S, Topalian Suzanne L, Iacobuzio-Donahue Christine A

Abstract excerpt

PURPOSE: Melanoma is a biologically heterogeneous disease composed of distinct clinicopathologic subtypes that frequently resist treatment. To explore the evolution of treatment resistance and metastasis, we used a combination of temporal and multilesional tumor sampling in conjunction with whole-exome sequencing of 110 tumors collected from 7 patients with cutaneous (n = 3), uveal (n = 2), and acral (n = 2)...

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Identifiers

PMID: 33323400
DOI: 10.1158/1078-0432.CCR-20-2984
PMCID: PMC7925434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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