Article
Enhanced measures of neoantigenicity capture unique tumor-immune interactions across primary melanoma subtypes.
Genome medicine - 26 May 2026
Shteinman Eva R, Attrill Grace H, Maher Nigel G, Gnana Kiran, Addala Venkateswar, Mao Yizhe, Palendira Umaimainthan, Conway Jordan W, Colebatch Andrew J, Waddell Nicola, Hayward Nicholas K, Pearson John V, Long Georgina V, Scolyer Richard A, Wilmott James S, Vergara Ismael A
Abstract excerpt
BACKGROUND: As immune checkpoint inhibitor therapies move toward treatment of clinically high-risk localized primary melanoma, there is an increasing need for clear understanding of the tumor-immune interaction across primary melanoma subtypes. Tumor genomic properties play a crucial role in the interaction with the immune system and have been widely explored in metastatic melanoma, but are less understood in the...
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