Article

Multi-site clonality analyses uncovers pervasive subclonal heterogeneity and branching evolution across melanoma metastases

2019-11-27

Abstract excerpt

Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding the evolution of the disease could help inform patient management. Through whole-genome sequencing of 13 melanoma metastases sampled at autopsy from a treatment naïve patient and by leveraging the analytical power of multi-sample analyses, we reveal that metastatic cells may depart the primary tumour very early in the dis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 61dd2774-62bf-503b-903a-0360ee29b068
DOI: 10.1101/848390

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-site clonality analyses uncovers pervasive subclonal heterogeneity and branching evolution across melanoma metastasesDOI 10.1101/848390Read

Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways.Semantic proximity Read

Phylogenetic analyses of melanoma reveal complex patterns of metastatic disseminationSemantic proximity Read

Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling.Semantic proximity Read

Patterns of genomic evolution in advanced melanoma.Semantic proximity Read

Multiregion Whole-Exome Sequencing Uncovers the Genetic Evolution and Mutational Heterogeneity of Early-Stage Metastatic Melanoma.Semantic proximity Read

Molecular and genetic diversity in the metastatic process of melanoma.Semantic proximity Read

Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma.Semantic proximity Read

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.Semantic proximity Read

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases.Semantic proximity Read

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastasesSemantic proximity Read

The Genetic Evolution of Treatment-Resistant Cutaneous, Acral, and Uveal Melanomas.Semantic proximity Read

Genetic Evolution of Melanoma: Comparative Analysis of Candidate Gene Mutations in Healthy Skin, Nevi, and Tumors from the Same Patients.Semantic proximity Read