Article
Late-Stage Metastatic Melanoma Emerges through a Diversity of Evolutionary Pathways.
Cancer discovery - 2 Jun 2023
Spain Lavinia, Coulton Alexander, Lobon Irene, Rowan Andrew, Schnidrig Desiree, Shepherd Scott T C, Shum Benjamin, Byrne Fiona, Goicoechea Maria, Piperni Elisa, Au Lewis, Edmonds Kim, Carlyle Eleanor, Hunter Nikki, Renn Alexandra, Messiou Christina, Hughes Peta, Nobbs Jaime, Foijer Floris, van den Bos Hilda, Wardenaar Rene, Spierings Diana C J, Spencer Charlotte, Schmitt Andreas M, Tippu Zayd, Lingard Karla, Grostate Lauren, Peat Kema, Kelly Kayleigh, Sarker Sarah, Vaughan Sarah, Mangwende Mary, Terry Lauren, Kelly Denise, Biano Jennifer, Murra Aida, Korteweg Justine, Lewis Charlotte, O'Flaherty Molly, Cattin Anne-Laure, Emmerich Max, Gerard Camille L, Pallikonda Husayn Ahmed, Lynch Joanna, Mason Robert, Rogiers Aljosja, Xu Hang, Huebner Ariana, McGranahan Nicholas, Al Bakir Maise, Murai Jun, Naceur-Lombardelli Cristina, Borg Elaine, Mitchison Miriam, Moore David A, Falzon Mary, Proctor Ian, Stamp Gordon W H, Nye Emma L, Young Kate, Furness Andrew J S, Pickering Lisa, Stewart Ruby, Mahadeva Ula, Green Anna, Larkin James, Litchfield Kevin, Swanton Charles, Jamal-Hanjani Mariam, Turajlic Samra
Abstract excerpt
Understanding the evolutionary pathways to metastasis and resistance to immune-checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present the most comprehensive intrapatient metastatic melanoma dataset assembled to date as part of the Posthumous Evaluation of Advanced Cancer Environment (PEACE) research autopsy program, including 222 exome sequencing, 493 panel-sequenced, 161 RNA...
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