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Article

HIV-1 APOBEC-context Mutations Detected by Next-Generation Sequencing in Plasma: Implications for Drug Resistance Interpretation.

The Journal of infectious diseases - 23 Sept 2026

Illescas-López Marta, Muñoz Báez Paloma, de Salazar Adolfo, Delgado Rafael, Iborra Asunción, Galán Juan Carlos, Carracedo Raquel, Sigcha Mayra, López-Causape Carla, Fuentes Ana, Aguilera Antonio, Marco-Sánchez Cristina, García Federico

Abstract excerpt

BACKGROUND: APOBEC3-mediated cytidine deamination produces G→A substitutions in HIV genomes, described in proviral DNA but detectable in plasma HIV-1 RNA using NGS. APOBEC-signature mutations reflect G→A enrichment substitutions, whereas APOBEC-context mutations are substitutions at drug resistance-associated positions compatible with APOBEC editing. We evaluated theirprevalence and impact on resistance...

Read the complete abstract on PubMed

Topics

Humans
HIV-1
High-Throughput Nucleotide Sequencing
HIV Infections
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Drug Resistance, Viral

APOBEC Deaminases

Retrospective Studies

RNA, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 42244370
DOI: 10.1093/infdis/jiag277
PMCID: PMC13600384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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