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Extremely High Mutation Rate of HIV-1 In Vivo

16 Sept 2015

Abstract excerpt

Rates of spontaneous mutation critically determine the genetic diversity and evolution of RNA viruses. Although these rates have been characterized in vitro and in cell culture models, they have seldom been determined in vivo for human viruses. Here, we use the intrapatient frequency of premature stop codons to quantify the HIV-1 genome-wide rate of spontaneous mutation in DNA sequences from peripheral blood...

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PMID: 26375597
DOI: 10.1371/journal.pbio.1002251

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