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Article

Sensitive HIV-1 DNA Pol Next-Generation Sequencing for the Characterisation of Archived Antiretroviral Drug Resistance.

Viruses - 25 Aug 2023

Botha Johannes C, Byott Matthew, Spyer Moira J, Grant Paul R, Gärtner Kathleen, Chen Wilson X, Burton James, Bamford Alasdair, Waters Laura J, Giaquinto Carlo, Turkova Anna, Vavro Cindy L, Nastouli Eleni

Abstract excerpt

Modern HIV-1 treatment effectively suppresses viral amplification in people living with HIV. However, the persistence of HIV-1 DNA as proviruses integrated into the human genome remains the main barrier to achieving a cure. Next-generation sequencing (NGS) offers increased sensitivity for characterising archived drug resistance mutations (DRMs) in HIV-1 DNA for improved treatment options. In this study, we...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 37766218
DOI: 10.3390/v15091811
PMCID: PMC10536450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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