Article
Presence of HIV-1 G-to-A mutations linked to APOBEC editing is more prevalent in non-B HIV-1 subtypes and is associated with lower HIV-1 reservoir.
The Journal of antimicrobial chemotherapy - 15 Jul 2021
Abdi Basma, Lambert-Niclot Sidonie, Wirden Marc, Jary Aude, Teyssou Elisa, Sayon Sophie, Palich Romain, Tubiana Roland, Simon Anne, Valantin Marc-Antoine, Katlama Christine, Morand-Joubert Laurence, Calvez Vincent, Marcelin Anne-Geneviève, Soulie Cathia
Abstract excerpt
OBJECTIVES: APOBEC3 editing activity contributes to sequences variation and viral diversification. We aimed to characterize virological and clinical factors associated with G-to-A mutations and stop codons in the HIV-1 reservoir, markers of APOBEC3 footprints, in order to better understand HIV-1 diversity among virologically suppressed HIV-1-infected patients. METHODS: Immuno-virological and clinical factors were...
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