Article
Use of next-generation sequencing on HIV-1 DNA to assess archived resistance in highly treatment-experienced people with multidrug-resistant HIV under virological control: data from the PRESTIGIO Registry.
The Journal of antimicrobial chemotherapy - 3 Sept 2024
Armenia Daniele, Spagnuolo Vincenzo, Bellocchi Maria C, Galli Laura, Duca Leonardo, Marchegiani Greta, Clemente Tommaso, Carioti Luca, Lolatto Riccardo, Calza Leonardo, Celesia Benedetto M, Cascio Antonio, Francisci Daniela, Saracino Annalisa, Torti Carlo, Zazzi Maurizio, Castagna Antonella, Santoro Maria M
Abstract excerpt
BACKGROUND: To clarify whether next-generation sequencing (NGS) can be useful for resistance assessment in virologically suppressed highly treatment-experienced (HTE) individuals with MDR HIV. METHODS: Ninety-one participants from the PRESTIGIO Registry were included. NGS was performed on HIV-DNA at 1%, 5% and 20% cut-offs; major drug resistance mutations (DRMs) were evaluated and compared with those detected in...
Topics
- Humans
- HIV Infections
- High-Throughput Nucleotide Sequencing
- HIV-1
- Male
- Female
- Adult
- Middle Aged
- Drug Resistance, Multiple, Viral