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Article

HIV-1 Protease, Reverse Transcriptase, and Integrase Variation.

Journal of virology - 1 Jul 2016

Rhee Soo-Yon, Sankaran Kris, Varghese Vici, Winters Mark A, Hurt Christopher B, Eron Joseph J, Parkin Neil, Holmes Susan P, Holodniy Mark, Shafer Robert W

Abstract excerpt

UNLABELLED: HIV-1 protease (PR), reverse transcriptase (RT), and integrase (IN) variability presents a challenge to laboratories performing genotypic resistance testing. This challenge will grow with increased sequencing of samples enriched for proviral DNA such as dried blood spots and increased...

Topics

APOBEC Deaminases
Amino Acid Sequence
Anti-HIV Agents
Drug Resistance, Viral
Genetic Variation
Genotype
HIV Infections
HIV Integrase
HIV Protease
HIV Reverse Transcriptase
HIV-1
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mutation

Reverse Transcriptase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 27099321
DOI: 10.1128/JVI.00495-16
PMCID: PMC4907232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-27099321-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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