Article
How should APOBEC3-induced resistance mutations be considered in the management of antiretroviral therapy?
The Journal of antimicrobial chemotherapy - 4 Nov 2025
Gilbert Marie, Ferré Valentine Marie, Guilbaud Romane, Digumber Marc, Peytavin Gilles, Damond Florence, Le Hingrat Quentin, Yazdanpanah Yazdan, Descamps Diane, Charpentier Charlotte, Joly Véronique, Ghosn Jade
Abstract excerpt
BACKGROUND: Combined antiretroviral therapy (ART) management guided by the cell-associated HIV-DNA genotypic resistance test (GRT) is not standardized, and its interpretation may be difficult in the presence of APOBEC3-induced mutations at drug resistance-associated positions (APOMut). Our objective was to evaluate the virologic outcome of people living with HIV (PLWH) with HIV-DNA provirus carrying APOMuts when...
Read the complete abstract on PubMedTopics
- Humans
- HIV Infections
- Drug Resistance, Viral
- Female
- Male
- Mutation