Drug resistance mutations in HIV provirus are associated with defective proviral genomes with hypermutation.

doi:10.1097/QAD.0000000000002850

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Article

Drug resistance mutations in HIV provirus are associated with defective proviral genomes with hypermutation.

AIDS (London, England) - 1 Jun 2021

Li Yijia, Etemad Behzad, Dele-Oni Ruth, Sharaf Radwa, Gao Ce, Lichterfeld Mathias, Li Jonathan Z

Abstract excerpt

BACKGROUND: HIV proviral sequencing overcomes the limit of plasma viral load requirement by detecting all the 'archived mutations', but the clinical relevance remains to be evaluated. METHODS: We included 25 participants with available proviral sequences (both intact and defective sequences avail...

Topics

Anti-HIV Agents
Drug Resistance, Viral
Genotype
HIV Infections
HIV-1
Humans
Mutation
Proviruses

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