Article
Drug resistance mutations in HIV provirus are associated with defective proviral genomes with hypermutation.
AIDS (London, England) - 1 Jun 2021
Li Yijia, Etemad Behzad, Dele-Oni Ruth, Sharaf Radwa, Gao Ce, Lichterfeld Mathias, Li Jonathan Z
Abstract excerpt
BACKGROUND: HIV proviral sequencing overcomes the limit of plasma viral load requirement by detecting all the 'archived mutations', but the clinical relevance remains to be evaluated. METHODS: We included 25 participants with available proviral sequences (both intact and defective sequences available) and utilized the genotypic sensitivity score (GSS) to evaluate the level of resistance in their provirus and...
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