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Inferring clonal somatic mutations directed by X chromosome inactivation status in single cells.

Genome biology - 9 Aug 2024

Demirci Ilke, Larsson Anton J M, Chen Xinsong, Hartman Johan, Sandberg Rickard, Frisén Jonas

Abstract excerpt

Analysis of clonal dynamics in human tissues is enabled by somatic genetic variation. Here, we show that analysis of mitochondrial mutations in single cells is dramatically improved in females when using X chromosome inactivation to select informative clonal mutations. Applying this strategy to human peripheral mononuclear blood cells reveals clonal structures within T cells that otherwise are blurred by...

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Share to Chromosomes, Human, X
Share to Clone Cells
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukocytes, Mononuclear

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Share to Single-Cell Analysis

Share to T-Lymphocytes

Share to X Chromosome Inactivation

Source

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Identifiers

PMID: 39123248
DOI: 10.1186/s13059-024-03360-1
PMCID: PMC11312698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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