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Article

Inverse relationship between neoantigen clonality and T-cell activity reveals distinct immune phenotypes in HNSCC.

Journal of translational medicine - 3 Jun 2026

Saravi Babak, Singh Daman Deep, Schorn Lara, Lommen Julian, Schrader Felix, Wilkat Max, Vollmer Andreas, Vollmer Michael, Hartmann Stefan, Hörner Marius, Adhikari Kaustubh, Roider Elisabeth, Wollborn Jakob, Kübler Norbert, Sproll Christoph

Abstract excerpt

BACKGROUND: Neoantigens derived from tumour-specific mutations are critical targets for T-cell recognition, yet the relationship between neoantigen clonality and immune response in head and neck squamous cell carcinoma (HNSCC) remains poorly understood. We hypothesised that clonal neoantigens, being present in all tumour cells, would drive T-cell exhaustion through persistent antigen exposure. METHODS: We...

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Share to Antigens, Neoplasm
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Head and Neck Neoplasms

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Share to Proportional Hazards Models

Share to Squamous Cell Carcinoma of Head and Neck

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Source

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Identifiers

PMID: 42237160
DOI: 10.1186/s12967-026-08371-z
PMCID: PMC13235206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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