Article
Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade.
Science (New York, N.Y.) - 25 Mar 2016
McGranahan Nicholas, Furness Andrew J S, Rosenthal Rachel, Ramskov Sofie, Lyngaa Rikke, Saini Sunil Kumar, Jamal-Hanjani Mariam, Wilson Gareth A, Birkbak Nicolai J, Hiley Crispin T, Watkins Thomas B K, Shafi Seema, Murugaesu Nirupa, Mitter Richard, Akarca Ayse U, Linares Joseph, Marafioti Teresa, Henry Jake Y, Van Allen Eliezer M, Miao Diana, Schilling Bastian, Schadendorf Dirk, Garraway Levi A, Makarov Vladimir, Rizvi Naiyer A, Snyder Alexandra, Hellmann Matthew D, Merghoub Taha, Wolchok Jedd D, Shukla Sachet A, Wu Catherine J, Peggs Karl S, Chan Timothy A, Hadrup Sine R, Quezada Sergio A, Swanton Charles
Abstract excerpt
As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored the impact of neoantigen intratumor heterogeneity (ITH) on antitumor immunity. Through integrated analysis of ITH and neoantigen burden, we demonstrate a relationship between clonal neoantigen burden and overall survival in primary lung adenocarcinomas....
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