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Article

The loss of neoantigens is an important reason for immune escape in multiple myeloma patients with high intratumor heterogeneity.

Cancer medicine - 1 Dec 2023

Wang Yue, Xu Jiadai, Lan Tianwei, Zhou Chi, Liu Peng

Abstract excerpt

OBJECTIVES: Intratumor heterogeneity (ITH) is an important factor for clinical outcomes in patients with multiple myeloma (MM). High ITH has been proven to be a key reason for tumor immune escape and treatment resistance. Neoantigens are thought to be associated with ITH, but the specific correlation and functional basis for this remains unclear. METHODS: We study this question through the whole-exome sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37965778
DOI: 10.1002/cam4.6721
PMCID: PMC10757111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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