Article
Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens.
Proceedings of the National Academy of Sciences of the United States of America - 19 Nov 2019
Linette Gerald P, Becker-Hapak Michelle, Skidmore Zachary L, Baroja Miren Lorea, Xu Chong, Hundal Jasreet, Spencer David H, Fu Weixuan, Cummins Casey, Robnett Maya, Kaabinejadian Saghar, Hildebrand William H, Magrini Vincent, Demeter Ryan, Krupnick Alexander S, Griffith Obi L, Griffith Malachi, Mardis Elaine R, Carreno Beatriz M
Abstract excerpt
The impact of intratumoral heterogeneity (ITH) and the resultant neoantigen landscape on T cell immunity are poorly understood. ITH is a widely recognized feature of solid tumors and poses distinct challenges related to the development of effective therapeutic strategies, including cancer neoantigen vaccines. Here, we performed deep targeted DNA sequencing of multiple metastases from melanoma patients and...
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