Article

NeoPrecis: Enhancing Immunotherapy Response Prediction through Integration of Qualified Immunogenicity and Clonality-Aware Neoantigen Landscapes

2025-07-27

Abstract excerpt

Despite the transformative impact of cancer immunotherapy, the need for improved patient stratification remains critical due to suboptimal response rates. While neoantigens are central to anti-tumor immunity, current metrics like tumor mutation burden are limited by their neglect of immunogenicity and tumor heterogeneity. We present NeoPrecis, a computational framework designed to refine neoantigen characterizatio...

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Literature Corpus work: b439f84a-a95f-5616-99ce-551de878c42c
DOI: 10.1101/2025.07.23.666355

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