Article
Neoantigen landscape in metastatic nasopharyngeal carcinoma.
Theranostics - 1 Jan 2021
Lin Mei, Zhang Xiao-Long, You Rui, Yang Qi, Zou Xiong, Yu Kai, Liu You-Ping, Zou Ru-Hai, Hua Yi-Jun, Huang Pei-Yu, Wang Jin, Zhao Qi, Jiang Xiao-Bing, Tang Jun, Gu Yang-Kui, Yu Tao, He Gui-Ping, Xie Yu-Long, Wang Zhi-Qiang, Liu Ting, Chen Si-Yuan, Zuo Zhi-Xiang, Chen Ming-Yuan
Abstract excerpt
Background: Reportedly, nasopharyngeal carcinoma (NPC) patients with MHC I Class aberration are prone to poor survival outcomes, which indicates that the deficiency of tumor neoantigens might represent a mechanism of immune surveillance escape in NPC. Methods: To clearly delineate the landscape of neoantigens in NPC, we performed DNA and RNA sequencing on paired primary tumor, regional lymph node metastasis and...
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