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Article

Pan-cancer deconvolution of tumour composition using DNA methylation.

Nature communications - 13 Aug 2018

Chakravarthy Ankur, Furness Andrew, Joshi Kroopa, Ghorani Ehsan, Ford Kirsty, Ward Matthew J, King Emma V, Lechner Matt, Marafioti Teresa, Quezada Sergio A, Thomas Gareth J, Feber Andrew, Fenton Tim R

Abstract excerpt

The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a DNA methylation-based approach to tumour cell fraction deconvolution, we report the integrated analysis of tumour composition and genomics across a wide spectrum of solid cancers. Initially studying head and neck squamous cell carcinoma, we identify two distinct tumour subgroups:...

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PMID: 30104673
DOI: 10.1038/s41467-018-05570-1
PMCID: PMC6089972

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