Computational Identification of Clonal Neoantigens in IDH-Wildtype Glioblastoma Through Integrated Genomic Filtering and HLA Prediction

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Glioblastoma (GBM) remains highly resistant to immunotherapy despite advances in neoantigen-based approaches. While whole-exome sequencing (WES) comprehensively identifies somatic mutations, resulting candidate pools are enriched for subclonal and passenger variants with limited immunogenic potential. We developed a data-driven pipeline integrating mutation fr...

Topics

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• Antigens, Neoplasm
• Artificial Intelligence
• HLA Antigens
• Immunotherapy and Immune Responses
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• T-Lymphocytes
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

8462c8a8-d2dc-5221-913b-4bd00b8a9719

DOI

10.21203/rs.3.rs-8351369/v1