Article
The Immune Microenvironment and Neoantigen Landscape of Aggressive Salivary Gland Carcinomas Differ by Subtype.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2020
Linxweiler Maximilian, Kuo Fengshen, Katabi Nora, Lee Mark, Nadeem Zaineb, Dalin Martin G, Makarov Vladimir, Chowell Diego, Dogan Snjezana, Ganly Ian, Hakimi A Ari, Wong Richard J, Riaz Nadeem, Ho Alan L, Chan Timothy A, Morris Luc G T
Abstract excerpt
PURPOSE: Salivary gland carcinomas (SGC) are rare, aggressive cancers with high rates of recurrence and distant metastasis. These factors, and a lack of active systemic therapies, contribute to poor clinical outcome. Response rates with immune checkpoint blockade have been low, although clinical data remain sparse. To improve the efficacy of therapies, a more comprehensive understanding of relevant molecular...
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