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Article

Endogenous retroviruses and neighboring genes are coordinately repressed by LSD1/KDM1A.

Genes & development - 15 Mar 2011

Macfarlan Todd S, Gifford Wesley D, Agarwal Saurabh, Driscoll Shawn, Lettieri Karen, Wang Jianxun, Andrews Shane E, Franco Laura, Rosenfeld Michael G, Ren Bing, Pfaff Samuel L

Abstract excerpt

Endogenous retroviruses (ERVs) constitute a substantial portion of mammalian genomes, and their retrotransposition activity helped to drive genetic variation, yet their expression is tightly regulated to prevent unchecked amplification. We generated a series of mouse mutants and embryonic stem (ES) cell lines carrying "deletable" and "rescuable" alleles of the lysine-specific demethylase LSD1/KDM1A. In the...

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Identifiers

PMID: 21357675
DOI: 10.1101/gad.2008511
PMCID: PMC3059833

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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