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Article

Associations between the Plasmodium falciparum genome and sickle haemoglobin identified in mild malaria cases from Ghana.

Malaria journal - 1 Jun 2026

Hamilton William L, Forster Annie J, Aniweh Yaw, Asoala Victor, Drury Eleanor, Rockett Kirk A, Awandare Gordon A, Kwiatkowski Dominic P, Band Gavin, Amenga-Etego Lucas N

Abstract excerpt

BACKGROUND: Heterozygosity for sickle haemoglobin (HbS) confers protection against severe malaria caused by the parasite Plasmodium falciparum. Recent work has suggested that this protective effect can depend on the parasite genotype: P. falciparum sickle-associated (Pfsa) variants were found disproportionately in individuals with severe malaria carrying HbS alleles in The Gambia and Kenya. Interactions between...

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Identifiers

PMID: 42226152
DOI: 10.1186/s12936-026-05956-3
PMCID: PMC13295231

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