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Evolutionary race: Malaria evolves to evade sickle cell protection.

Cell host & microbe - 9 Feb 2022

Gómez-Díaz Elena, Ranford-Cartwright Lisa

Abstract excerpt

Sickle cell haemoglobin (HbS) confers protection, albeit incomplete, from severe malaria. A recent study by Band et al. in Nature on parasite genomic variation of severe malaria cases identifies parasite genomic regions with alleles associated with severe disease risk in HbS individuals. The protective effect of HbS depends therefore on parasite genotype.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35143762
DOI: 10.1016/j.chom.2022.01.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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