Malaria protection due to sickle haemoglobin depends on parasite genotype.

doi:10.1038/s41586-021-04288-3

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Article

Malaria protection due to sickle haemoglobin depends on parasite genotype.

Nature - 1 Feb 2022

Band Gavin, Leffler Ellen M, Jallow Muminatou, Sisay-Joof Fatoumatta, Ndila Carolyne M, Macharia Alexander W, Hubbart Christina, Jeffreys Anna E, Rowlands Kate, Nguyen Thuy, Gonçalves Sónia, Ariani Cristina V, Stalker Jim, Pearson Richard D, Amato Roberto, Drury Eleanor, Sirugo Giorgio, d'Alessandro Umberto, Bojang Kalifa A, Marsh Kevin, Peshu Norbert, Saelens Joseph W, Diakité Mahamadou, Taylor Steve M, Conway David J, Williams Thomas N, Rockett Kirk A, Kwiatkowski Dominic P

Abstract excerpt

Host genetic factors can confer resistance against malaria1, raising the question of whether this has led to evolutionary adaptation of parasite populations. Here we searched for association between candidate host and parasite genetic variants in 3,346 Gambian and Kenyan children with severe malaria caused by Plasmodium falciparum. We identified a strong association between sickle haemoglobin (HbS) in the host...

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PMID: 34883497
DOI: 10.1038/s41586-021-04288-3
PMCID: PMC8810385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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