Article

Sickle cell status skews malaria parasite genotype at infection

2025-09-12

Abstract excerpt

Sickle hemoglobin (HbS) confers strong protection against symptomatic malaria caused by Plasmodium falciparum . Recently, several P. falciparum alleles (termed Pfsa+ ) were found to be enriched in HbS carriers with malaria, suggesting that parasites may be evolving to overcome HbS protection. However, it is unclear whether HbS places selective pressure on parasites since it has little to no effect against asymp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b0f661e7-336b-509d-bc76-edd7bcfcfcc7
DOI: 10.1101/2025.09.09.675015

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sickle cell status skews malaria parasite genotype at infectionDOI 10.1101/2025.09.09.675015Read

Malaria protection due to sickle haemoglobin depends on parasite genotype.Semantic proximity Read

Evolutionary race: Malaria evolves to evade sickle cell protection.Semantic proximity Read

Influence of the sickle cell trait on Plasmodium falciparum infectivity from naturally infected gametocyte carriersSemantic proximity Read

Human genetic variations conferring resistance to malaria.Semantic proximity Read

Associations between the Plasmodium falciparum genome and sickle haemoglobin identified in mild malaria cases from Ghana.Semantic proximity Read

Geographical variation drives adaptive equilibrium of the <i>P. falciparum</i> sickle-associated mutationsSemantic proximity Read

Comparative haematological parameters of HbAA and HbAS genotype children infected with Plasmodium falciparum malaria in Yemen.Semantic proximity Read

Association of the sickle cell trait and the ABO blood group with clinical severity of malaria in southwest Nigeria.Semantic proximity Read

<em>Plasmodium falciparum</em> (<em>Pf</em>), Coevolutionary Balance, and Therapeutically-Rational Exchange Transfusion (T-REX): Nearly All <em>Pf</em> Genomes Allow HbAS Hemoglobin to Promote Human SurvivalSemantic proximity Read

Association between haematological parameters and sickle cell genotypes in children with Plasmodium falciparum malaria residents in Kisumu County in western KenyaSemantic proximity Read

An Immune Basis for Malaria Protection by the Sickle Cell TraitSemantic proximity Read

Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria PathogenesisSemantic proximity Read