Article
Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania.
PLoS genetics - 1 Jan 2018
Ravenhall Matt, Campino Susana, Sepúlveda Nuno, Manjurano Alphaxard, Nadjm Behzad, Mtove George, Wangai Hannah, Maxwell Caroline, Olomi Raimos, Reyburn Hugh, Drakeley Christopher J, Riley Eleanor M, Clark Taane G
Abstract excerpt
Significant selection pressure has been exerted on the genomes of human populations exposed to Plasmodium falciparum infection, resulting in the acquisition of mechanisms of resistance against severe malarial disease. Many host genetic factors, including sickle cell trait, have been associated with reduced risk of developing severe malaria, but do not account for all of the observed phenotypic variation....
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