Genomic analysis reveals multi-level resistance network linking oxidative stress pathway mutations to cefiderocol resistance and clonal evolution in Klebsiella pneumoniae from the United Arab Emirates.

Abstract excerpt

Introduction: Resistance to cefiderocol (CFDC), a novel siderophore-cephalosporin, remains poorly understood. We aimed to explore mutations in oxidative stress (OS) pathways in Klebsiella pneumoniae (KPN) and investigate their potential association with reduced susceptibility to CFDC. Methods: A total of 282 KPN strains from the United Arab Emirates were tested for susceptibility to various antibiotics, including...

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